主要科教成果 |
[1] Bi X, Li F, Liu S, Jin Y, Zhang X, Yang T, Dai Y, Li X,Zhao AZ*. (2017) ω-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity. J Clin Invest. 2017 May 1;127(5):1757-1771. [2] Cheng, Lixian，Shi, Hui，Jin, Yan，Li, Xiaoxi，Pan, Jinshun，Lai, Yimei，Lin, Yan，Jin, Ya，Roy, Gaurab，Zhao, Allan*，Li, Fanghong*. (2016) Adiponect in Deficiency Leads to Female Subfertility and Ovarian Dysfunctions in Mice.，Endocrinology，157(12)：4875~4887. [3] Li, Jie，Wei, Dong，McCrory, Mark A，Szalai, Alexander J，Yang, Gangyi，Li, Ling，Li, Fanghong(*)，Zhao, Allan Z *. (2016) Human C-reactive protein impedes entry of leptin into the CNS and attenuates its physiological actions in the CNS.，Biochem J，473(9): 1215~1224. [4] Zhou S, Zhao Z, Lin Y, Gong S, Li F, Pan J, Li X, Gao Z,Zhao AZ*. (2016) Suppression of pancreatic ductal adenocarcinoma growth by intratumoral delivery of attenuated Salmonella typhimurium using a dual fluorescent live tracking system. Cancer Biol Ther, 17(7):732-40. [5] Pan J, Cheng L, Bi X, Zhang X, Liu S, Bai X, Li F,Zhao AZ*. (2015) Elevation of ω-3 Polyunsaturated Fatty Acids Attenuates PTEN-deficiency Induced Endometrial Cancer Development through Regulation of COX-2 and PGE2 Production. Sci Rep. 5:14958. [6] Wei, D., Li, J., Shen, MD, Jia,W, Tian,H., Dai,Y., andZhao, AZ *. (2010) Cellular Production of n-3 PUFAs and Reduciton of n-6/n-3 ratios in the Pancreatic b-cells and Islets Enhance Insulin Secretion and Confer Protection against Cytokine-induced Cell Death. Diabetes. 59: 471-478. [7] Cong L, Gasser J, Zhao J, Yang B, Li F,Zhao AZ *.(2007) Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95- Endocr Relat Cancer. 14(3): 713-20. [8] Cong L, Chen K, Li J, Gao P, Li Q, Mi S, Wu X,Zhao AZ *. (2007) Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes. Biochem J. 403(3): 519-25. [9] Chen, K., Li, FH, Li, J., Cai, H., Strom, S., Bisello, A., Friedman-Einat, M., Kelley, DE, McCroy, M., Szalai, A.,Zhao, AZ *. (2006) Induction of Leptin Resistance through Direct Interaction ofC-Reactive Protein with Leptin. Nature Medicine 12: 425-432. [10] Li, J, Li, F, andZhao, AZ *. (2006) Inflammation and Leptin，Drug Discovery Today: Disease Mechanisms 3 (3): 387-393. [11] Huan, J.N., Li, J., Han, Y.P., Chen, K., Wu, N., andZhao, A.Z*. (2003) Adipocyte-Selective Reduction of the Leptin Receptors Induced by Antisense-RNA Leads to Increased Adiposity, Dyslipidemia and Insulin Resistance. J. Biol. Chem. 278: 45638-45650. [12]Zhao, A.Z., Huan, J.N. and Sahu, A. (2002) Requirement of a PI3K-PDE3B-cAMP Pathway for the Satiety Function of Leptin in the Hypothalamus. Nature Neuroscience 5:727-728. [13]Zhao, A.Z., Shinohara, M., Huang, D., Eldar-Finkelman, H., Krebs, E.G., Beavo, J.A. and Bornfeldt, K.E. (2000) Leptin Antagonizes the Action of Glucagon by Activating Phosphodiesterase 3B in Primary Hepatocytes. J. Biol. Chem. 275:11348-11354. [14]Zhao, A.Z., Bornfeldt, K.E., and Beavo, JA. (1998) Leptin Inhibition of Insulin Secretion through Activation of Phosphodiesterase 3B.J. Clinc. Inves. 102: 869-873. [15]Zhao, A.Z., Zhao, H., Teague, J., Fujimoto, W., and Beavo, J.A. (1997) Attenuation of Insulin Secretion by Insulin-like Growth Factor 1 Is Mediated through Activation of Phosphodiesterase 3B. Proc. Natl. Acad. U.S.A. 94: 3223-3228.近年授权的专利： 1 GENETICALLY ENGINEERED BACTERIUM FOR TREATMENT OF BREAST CANCER, METHOD FOR CONSTRUCTING THE BACTERIUM, AND APPLICATIONS THEREO，发明专利，美国，专利号14766558，授权公告日2017-09-13 2 APPLICATION OF AN ATTENUATED SALMONELLA TYPHIMURIUM发明专利，美国，专利号9439934，授权公告日2016-08-24 3 GENETICALLY ENGINEERED BACTERIUM FOR TREATMENT OF BREAST CANCER，发明专利，澳大利亚，专利号2014223112，授权公告日2017-02-03 4减毒鼠伤寒沙门氏菌及其基因工程菌在制备治疗胰腺癌的药物上的应用，发明专利，中国，专利号ZL201310688936.3，授权公告日2016-02-24 5一种治疗乳腺癌的基因工程菌及其构建方法和应用，发明专利，中国，专利号ZL201310062253.7，授权公告日2014-12-31 6减毒鼠伤寒沙门氏菌及其基因工程菌在制备治疗前列腺癌的药物上的应用，发明专利，中国，专利号ZL201410183149.8，授权公告日2018-08-08 7 COMPOSTITIONS FOR BLOCKING THE INHIBITORY EFFECT OF发明专利，美国，专利号7629315授权公告日2009-12-08 申请中专利： 1基因工程菌VNP20009-M在制备预防和治疗肺癌药物中的应用，发明专利，中国香港，专利申请号18100076.7，申请日期2018-01-03，初步审查阶段 2基因工程菌VNP20009-M在制备治疗恶性肉瘤药物中的应用，发明专利，中国香港，专利申请号18101397.7，申请日期2018-01-29，初步审查阶段 3基因工程菌VNP20009-M在制备预防和治疗癌症转移的药物上的应用，发明专利，中国，专利申请号2016100812709申请日期2016-02-05，实质审查阶段 |
